Last weekend was of the utmost importance for every 2-2 team. The difference between 2-3 and 3-2 might only be a game but each record feels massively different. Now, in Week 6, it's up to those teams that lost to find their footing as we approach midseason.

Week 6 kicks off with a Thursday night showdown between the San Francisco 49ers and Seattle Seahawks. The 49ers are coming off a disheartening defeat to the Arizona Cardinals. Two of the 49ers three losses have come after obtaining big leads. We know Kyle Shanahan has a knack for blowing leads like that, but the 49ers are still Super Bowl hopefuls and need to figure out their issues if they want to compete in the NFC West.

On Sunday, the Jacksonville Jaguars return to London to take on the Chicago Bears. Sunday night will feature Cincinnati Bengals taking on the New York Giants, fresh off a stunning victory over the Seahawks. Then, Monday Night Football will finish the week off with an AFC East showdown between the New York Jets and Buffalo Bills.

Take a look at all the odds and our expert predictions for this week's matchups.

New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites. Here are the NFL betting odds for Week 5, according to the BetMGM NFL odds.

NFL STATS CENTRAL: The latest NFL scores, schedules, odds, stats and more.

PROP TALK: These are the best prop bets for NFL games this week 

NFL Week 6 picks/predictions

• Seahawks vs. 49ers
• Bears vs. Jaguars
• Ravens vs. Commanders
• Packers vs. Cardinals
• Patriots vs. Texans
• Saints vs. Buccaneers
• Eagles vs. Browns
• Titans vs. Colts
• Broncos vs. Chargers
• Raiders vs. Steelers
• Panthers vs. Falcons
• Cowboys vs. Lions
• Giants vs. Bengals 
• Jets vs. Bills

NFL Week 6 point spreads

• San Francisco 49ers (-3.5) at Seattle Seahawks
• Jacksonville Jaguars (+2.5) vs. Chicago Bears
• Washington Commanders (+6.5) at Baltimore Ravens
• Arizona Cardinals (+5) at Green Bay Packers
• Houston Texans (-7) at New England Patriots
• Tampa Bay Buccaneers (-3.5) at New Orleans Saints
• Cleveland Browns (+8.5) at Philadelphia Eagles
• Indianapolis Colts (-1) at Tennessee Titans
• Los Angeles Chargers (-3) at Denver Broncos
• Pittsburgh Steelers (-3) at Las Vegas Raiders
• Atlanta Falcons (-6) at Carolina Panthers
• Detroit Lions (-3) at Dallas Cowboys
• Cincinnati Bengals (-3.5) at New York Giants
• Buffalo Bills (-2.5) at New York Jets

NFL Week 6 moneylines

• San Francisco 49ers (-190) at Seattle Seahawks (+155)
• Jacksonville Jaguars (+120) vs. Chicago Bears (-145)
• Washington Commanders (+240) at Baltimore Ravens (-300)
• Arizona Cardinals (+190) at Green Bay Packers (-250)
• Houston Texans (+240) at New England Patriots (-300)
• Tampa Bay Buccaneers (-200) at New Orleans Saints (+165)
• Cleveland Browns (+350) at Philadelphia Eagles (-450)
• Indianapolis Colts (-115) at Tennessee Titans (-105)
• Los Angeles Chargers (-165) at Denver Broncos (+140)
• Pittsburgh Steelers (-155) at Las Vegas Raiders (+130)
• Atlanta Falcons (-275) at Carolina Panthers (+220)
• Detroit Lions (-165) at Dallas Cowboys (+140)
• Cincinnati Bengals (-185) at New York Giants (+150)
• Buffalo Bills (-145) at New York Jets (+120)

NFL Week 6 over/under

• San Francisco 49ers at Seattle Seahawks: 47.5
• Jacksonville Jaguars vs. Chicago Bears: 44.5
• Washington Commanders at Baltimore Ravens: 52.5
• Arizona Cardinals at Green Bay Packers: 49.5
• Houston Texans at New England Patriots: 38
• Tampa Bay Buccaneers at New Orleans Saints: 41.5
• Cleveland Browns at Philadelphia Eagles: 43.5
• Indianapolis Colts at Tennessee Titans: 42.5
• Los Angeles Chargers at Denver Broncos: 35.5
• Pittsburgh Steelers at Las Vegas Raiders: 36.5
• Atlanta Falcons at Carolina Panthers: 47.5
• Detroit Lions at Dallas Cowboys: 52.5
• Cincinnati Bengals at New York Giants: 49
• Buffalo Bills at New York Jets: 41